SMAD2 promotes myogenin expression and terminal myogenic differentiation
نویسندگان
چکیده
منابع مشابه
c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation.
In vertebrate development, a prominent feature of several cell lineages is the coupling of cell cycle regulation with terminal differentiation. We have investigated the basis of this relationship in the skeletal muscle lineage by studying the effects of the proliferation-associated regulator, c-myc, on the differentiation of MyoD-initiated myoblasts. Transient cotransfection assays in NIH 3T3 c...
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Jing Zhang E-mail: [email protected] Zheng-zhou Ying E-mail: [email protected] Zhong-lin Tang Corresponding author. Fax/ Tel: +86 01062813822 Email addresses: [email protected] Liang-qi Long Co-corresponding author E-mail: [email protected] Kui Li E-mail: [email protected] To whom correspondence should be addressed: Zhong-lin Tang, Ph.D, Department of Gen...
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Kindlin 2, as an integrin-associated protein, is required for myocyte elongation and fusion. However, the association of Kindlin 2 with muscle differentiation-related signaling pathways is unknown. Here, we identified a mechanism that Kindlin 2 regulates myogenic regulatory factors myogenin via a canonical Wnt/β-catenin signaling. We found that knockdown of Kindlin 2 leads to the abolishment of...
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Certain higher vertebrates developed the ability to reverse muscle cell differentiation (dedifferentiation) as an additional mechanism to regenerate muscle. Mammals, on the other hand, show limited ability to reverse muscle cell differentiation. Myogenic Regulatory Factors (MRFs), MyoD, myogenin, Myf5 and Myf6 are basic-helix-loop-helix (bHLH) transcription factors essential towards the regulat...
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ژورنال
عنوان ژورنال: Development
سال: 2021
ISSN: 0950-1991,1477-9129
DOI: 10.1242/dev.195495